Assay Detail
Binding
CHEMBL870696
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Binding affinity to recombinant MMP1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.23 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 9.52 |
| CHEMBL382705 | — | — | 1 | 9.15 |
| CHEMBL208181 | — | — | 1 | 9.15 |
| CHEMBL72511 | — | — | 1 | 9.00 |
| CHEMBL439330 | — | — | 1 | 7.64 |
| CHEMBL207756 | — | — | 1 | 7.60 |
| CHEMBL438964 | — | — | 1 | 7.08 |
| CHEMBL206875 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115653 | CIPEMASTAT | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL382705 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL208181 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL72511 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL439330 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL207756 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL438964 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL206875 | — | Ki | = | 213.0 | nM | 6.67 |