Assay Detail
Binding
CHEMBL870710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli DXR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL4091) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.03 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.32 |
| CHEMBL204406 | — | — | 1 | 7.30 |
| CHEMBL205338 | FR-900098 | — | 1 | 7.24 |
| CHEMBL380319 | — | — | 1 | 6.80 |
| CHEMBL205091 | — | — | 1 | 6.50 |
| CHEMBL381270 | — | — | 1 | - |
| CHEMBL382795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL204406 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL205338 | FR-900098 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL380319 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL205091 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL381270 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL382795 | — | IC50 | > | 30000.0 | nM | - |