Assay Detail
Binding
CHEMBL870841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR tyrosine kinase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.98 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209343 | — | — | 1 | 8.40 |
| CHEMBL50344 | — | — | 1 | 8.30 |
| CHEMBL208594 | — | — | 1 | 7.96 |
| CHEMBL207009 | — | — | 1 | 7.75 |
| CHEMBL210444 | — | — | 1 | 7.66 |
| CHEMBL52765 | — | — | 1 | 7.36 |
| CHEMBL210660 | — | — | 1 | 7.33 |
| CHEMBL210659 | — | — | 1 | 7.17 |
| CHEMBL208144 | — | — | 1 | 7.09 |
| CHEMBL379047 | — | — | 1 | 6.81 |
| CHEMBL343352 | — | — | 1 | 6.70 |
| CHEMBL210378 | — | — | 1 | 6.69 |
| CHEMBL210893 | — | — | 1 | 6.53 |
| CHEMBL208240 | — | — | 1 | 6.17 |
| CHEMBL336113 | — | — | 1 | 6.00 |
| CHEMBL210502 | — | — | 1 | 5.97 |
| CHEMBL209818 | — | — | 1 | 5.94 |
| CHEMBL208849 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209343 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL50344 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL208594 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL207009 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL210444 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL52765 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL210660 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL210659 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL208144 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL379047 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL343352 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL210378 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL210893 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL208240 | — | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL336113 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL210502 | — | IC50 | = | 1061.0 | nM | 5.97 |
| CHEMBL209818 | — | IC50 | = | 1139.0 | nM | 5.94 |
| CHEMBL208849 | — | IC50 | = | 1693.0 | nM | 5.77 |