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Assay Detail

CHEMBL870845

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CPX from human adenosine A3 receptor expressed in CHO cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.
Kalla RV, Elzein E, Perry T, Li X, Palle V, Varkhedkar V, Gimbel A, Maa T, Zeng D, Zablocki J.
J Med Chem (2006) 49 : 3682 -3692
PubMed 16759111 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 50 6.81 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] 1 9.05
CHEMBL380284 1 8.15
CHEMBL209217 1 7.77
CHEMBL210649 1 7.72
CHEMBL380176 1 7.70
CHEMBL210747 1 7.66
CHEMBL379474 1 7.64
CHEMBL210938 1 7.51
CHEMBL210150 1 7.47
CHEMBL207524 1 7.42
CHEMBL207434 1 7.39
CHEMBL208110 1 7.36
CHEMBL378570 1 7.32
CHEMBL378652 1 7.23
CHEMBL380219 1 7.23
CHEMBL210683 1 7.16
CHEMBL254725 1 7.12
CHEMBL210319 1 7.11
CHEMBL251869 1 6.77
CHEMBL251870 1 6.77
CHEMBL210212 1 6.77
CHEMBL209174 1 6.72
CHEMBL426504 1 6.42
CHEMBL210609 1 6.41
CHEMBL273807 1 6.40
CHEMBL261722 1 6.34
CHEMBL210213 1 6.28
CHEMBL210271 1 6.24
CHEMBL210808 1 6.24
CHEMBL441530 1 6.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] Ki = 0.9 nM 9.05
CHEMBL380284 Ki = 7.0 nM 8.15
CHEMBL209217 Ki = 17.0 nM 7.77
CHEMBL210649 Ki = 19.0 nM 7.72
CHEMBL380176 Ki = 20.0 nM 7.70
CHEMBL210747 Ki = 22.0 nM 7.66
CHEMBL379474 Ki = 23.0 nM 7.64
CHEMBL210938 Ki = 31.0 nM 7.51
CHEMBL210150 Ki = 34.0 nM 7.47
CHEMBL207524 Ki = 38.0 nM 7.42
CHEMBL207434 Ki = 41.0 nM 7.39
CHEMBL208110 Ki = 44.0 nM 7.36
CHEMBL378570 Ki = 48.0 nM 7.32
CHEMBL380219 Ki = 59.0 nM 7.23
CHEMBL378652 Ki = 59.0 nM 7.23
CHEMBL210683 Ki = 70.0 nM 7.16
CHEMBL254725 Ki = 76.0 nM 7.12
CHEMBL210319 Ki = 77.0 nM 7.11
CHEMBL251869 Ki = 170.0 nM 6.77
CHEMBL251870 Ki = 170.0 nM 6.77
CHEMBL210212 Ki = 170.0 nM 6.77
CHEMBL209174 Ki = 190.0 nM 6.72
CHEMBL426504 Ki = 380.0 nM 6.42
CHEMBL210609 Ki = 390.0 nM 6.41
CHEMBL273807 Ki = 400.0 nM 6.40
CHEMBL261722 Ki = 460.0 nM 6.34
CHEMBL210213 Ki = 530.0 nM 6.28
CHEMBL210271 Ki = 580.0 nM 6.24
CHEMBL210808 Ki = 570.0 nM 6.24
CHEMBL441530 Ki = 620.0 nM 6.21
CHEMBL209831 Ki = 770.0 nM 6.11
CHEMBL378743 Ki = 830.0 nM 6.08
CHEMBL208824 Ki = 990.0 nM 6.00
CHEMBL378598 Ki = 1200.0 nM 5.92
CHEMBL383201 Ki = 1400.0 nM 5.85
CHEMBL208920 Ki = 3100.0 nM 5.51
CHEMBL1355736 THEOPHYLLINE Ki = 6920.0 nM 5.16
CHEMBL279898 ENPROFYLLINE Ki = 42000.0 nM 4.38
CHEMBL408186 Ki > 1000.0 nM -
CHEMBL437301 Ki > 6000.0 nM -
CHEMBL378020 Ki - -
CHEMBL210614 Ki - -
CHEMBL208143 Ki - -
CHEMBL208723 Ki - -
CHEMBL210565 Ki - -
CHEMBL210482 Ki - -
CHEMBL210890 Ki - -
CHEMBL379032 Ki - -
CHEMBL207482 Ki - -
CHEMBL211038 Ki - -