Assay Detail
Functional
CHEMBL870949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human OTR expressed in CHO cells measured as calcium influx by FLIPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.60 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377414 | — | — | 1 | 8.80 |
| CHEMBL208787 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377414 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL208787 | — | Ki | = | 3.981 | nM | 8.40 |