Assay Detail
Functional
CHEMBL870966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction in oxytocin-induced uterine contraction in iv dosed anaesthetized rat
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| IC50 | 2 | 6.69 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382301 | ATOSIBAN | 4.0 | 2 | 6.73 |
| CHEMBL377414 | — | — | 2 | 6.64 |
| CHEMBL208787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382301 | ATOSIBAN | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL377414 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL382301 | ATOSIBAN | Activity | = | 0.63 | mg kg-1 | - |
| CHEMBL208787 | — | Activity | = | 5.4 | mg kg-1 | - |
| CHEMBL377414 | — | Activity | = | 0.22 | mg kg-1 | - |