Assay Detail
Binding
CHEMBL870967
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Displacement of [3H]oxytocin from rat OTR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.53 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377414 | — | — | 1 | 8.00 |
| CHEMBL382301 | ATOSIBAN | 4.0 | 1 | 7.40 |
| CHEMBL208787 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377414 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL382301 | ATOSIBAN | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL208787 | — | Ki | = | 63.1 | nM | 7.20 |