Assay Detail
Binding
CHEMBL870979
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Inhibition of p38alpha
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.00 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427047 | — | — | 1 | 6.80 |
| CHEMBL212143 | — | — | 1 | 6.75 |
| CHEMBL442485 | — | — | 1 | 6.70 |
| CHEMBL215847 | — | — | 1 | 6.50 |
| CHEMBL211460 | — | — | 1 | 6.38 |
| CHEMBL385898 | — | — | 1 | 6.37 |
| CHEMBL215730 | — | — | 1 | 6.36 |
| CHEMBL386760 | — | — | 1 | 6.28 |
| CHEMBL377481 | — | — | 1 | 6.13 |
| CHEMBL211845 | — | — | 1 | 6.00 |
| CHEMBL264803 | — | — | 1 | 5.92 |
| CHEMBL263769 | — | — | 1 | 5.92 |
| CHEMBL215289 | — | — | 1 | 5.89 |
| CHEMBL213100 | — | — | 1 | 5.89 |
| CHEMBL209908 | — | — | 1 | 5.75 |
| CHEMBL212721 | — | — | 1 | 5.68 |
| CHEMBL214775 | — | — | 1 | 5.68 |
| CHEMBL379080 | — | — | 1 | 5.64 |
| CHEMBL212668 | — | — | 1 | 5.52 |
| CHEMBL379733 | — | — | 1 | 5.50 |
| CHEMBL215411 | — | — | 1 | 5.17 |
| CHEMBL215726 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427047 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL212143 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL442485 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL215847 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL211460 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL385898 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL215730 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL386760 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL377481 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL211845 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL264803 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL263769 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL215289 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL213100 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL209908 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL212721 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL214775 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL379080 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL212668 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL379733 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL215411 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL215726 | — | IC50 | = | 8000.0 | nM | 5.10 |