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Assay Detail

CHEMBL871012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against mouse NIH3T3 cell line
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Intermediate

Target

NIH3T3 (CHEMBL614822)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis of 13-amino costunolide derivatives as anticancer agents.
Srivastava SK, Abraham A, Bhat B, Jaggi M, Singh AT, Sanna VK, Singh G, Agarwal SK, Mukherjee R, Burman AC.
Bioorg Med Chem Lett (2006) 16 : 4195 -4199
PubMed 16766184 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.67 4.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL86416 COSTUNOLIDE 1 4.86
CHEMBL209170 1 4.80
CHEMBL379127 1 4.77
CHEMBL213622 1 4.75
CHEMBL374848 1 4.73
CHEMBL211721 1 4.71
CHEMBL214292 1 4.71
CHEMBL377003 1 4.70
CHEMBL212687 1 4.64
CHEMBL373564 1 4.59
CHEMBL211718 1 4.55
CHEMBL211817 1 4.46
CHEMBL406137 1 4.39
CHEMBL209999 1 -
CHEMBL438057 1 -
CHEMBL211682 1 -
CHEMBL425070 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL86416 COSTUNOLIDE IC50 = 13900.0 nM 4.86
CHEMBL209170 IC50 = 15700.0 nM 4.80
CHEMBL379127 IC50 = 17100.0 nM 4.77
CHEMBL213622 IC50 = 17900.0 nM 4.75
CHEMBL374848 IC50 = 18500.0 nM 4.73
CHEMBL211721 IC50 = 19700.0 nM 4.71
CHEMBL214292 IC50 = 19300.0 nM 4.71
CHEMBL377003 IC50 = 19900.0 nM 4.70
CHEMBL212687 IC50 = 22800.0 nM 4.64
CHEMBL373564 IC50 = 25800.0 nM 4.59
CHEMBL211718 IC50 = 28300.0 nM 4.55
CHEMBL211817 IC50 = 34700.0 nM 4.46
CHEMBL406137 IC50 = 40800.0 nM 4.39
CHEMBL209999 IC50 - -
CHEMBL438057 IC50 - -
CHEMBL211682 IC50 - -
CHEMBL425070 IC50 - -