Assay Detail
Binding
CHEMBL871072
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Displacement of [3H]DAMGO from mu opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.84 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143820 | — | — | 1 | 9.89 |
| CHEMBL3143819 | — | — | 1 | 9.82 |
| CHEMBL3143821 | — | — | 1 | 9.80 |
| CHEMBL3143818 | — | — | 1 | 9.43 |
| CHEMBL2028971 | — | — | 1 | 9.20 |
| CHEMBL2028972 | — | — | 1 | 9.03 |
| CHEMBL2028970 | — | — | 1 | 8.83 |
| CHEMBL2028969 | — | — | 1 | 8.39 |
| CHEMBL2028967 | — | — | 1 | 8.36 |
| CHEMBL2028968 | — | — | 1 | 8.26 |
| CHEMBL2371927 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143820 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL3143819 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL3143821 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL3143818 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL2028971 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL2028972 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL2028970 | — | Ki | = | 1.47 | nM | 8.83 |
| CHEMBL2028969 | — | Ki | = | 4.05 | nM | 8.39 |
| CHEMBL2028967 | — | Ki | = | 4.41 | nM | 8.36 |
| CHEMBL2028968 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL2371927 | — | Ki | = | 529.0 | nM | 6.28 |