Assay Detail
Functional
CHEMBL871087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mu opioid receptor assessed as inhibition of endomorphin-2-induced contraction of guinea pig ileum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.31 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028968 | — | — | 1 | 8.16 |
| CHEMBL2028969 | — | — | 1 | 7.96 |
| CHEMBL2028967 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028968 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL2028969 | — | Kd | = | 10.96 | nM | 7.96 |
| CHEMBL2028967 | — | Kd | = | 1513.56 | nM | 5.82 |