Assay Detail
Binding
CHEMBL871198
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Inhibition of human cathepsin K
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Keto-1,3,4-oxadiazoles as cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.78 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209293 | — | — | 1 | 9.02 |
| CHEMBL209215 | — | — | 1 | 8.77 |
| CHEMBL379622 | — | — | 1 | 8.48 |
| CHEMBL209114 | — | — | 1 | 8.28 |
| CHEMBL405602 | — | — | 1 | 8.10 |
| CHEMBL379157 | — | — | 1 | 7.72 |
| CHEMBL210198 | — | — | 1 | 7.66 |
| CHEMBL211050 | — | — | 1 | 7.54 |
| CHEMBL210535 | — | — | 1 | 7.46 |
| CHEMBL376994 | — | — | 1 | 7.43 |
| CHEMBL209216 | — | — | 1 | 7.37 |
| CHEMBL208566 | — | — | 1 | 7.27 |
| CHEMBL210625 | — | — | 1 | 6.92 |
| CHEMBL210702 | — | — | 1 | 6.30 |
| CHEMBL208577 | — | — | 1 | 6.26 |
| CHEMBL210315 | — | — | 1 | 6.09 |
| CHEMBL209181 | — | — | 1 | 5.89 |
| CHEMBL210759 | — | — | 1 | 5.52 |
| CHEMBL209766 | — | — | 1 | 5.25 |
| CHEMBL210712 | — | — | 1 | 5.02 |
| CHEMBL378780 | — | — | 1 | 4.77 |
| CHEMBL210523 | — | — | 1 | 4.48 |
| CHEMBL209294 | — | — | 1 | 4.28 |
| CHEMBL378899 | — | — | 1 | - |
| CHEMBL207347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209293 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL209215 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL379622 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL209114 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL405602 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL379157 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL210198 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL211050 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL210535 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL376994 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL209216 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL208566 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL210625 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL210702 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL208577 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL210315 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL209181 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL210759 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL209766 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL210712 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL378780 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL210523 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL209294 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL378899 | — | Ki | < | 0.25 | nM | - |
| CHEMBL207347 | — | Ki | < | 0.25 | nM | - |