Assay Detail
Binding
CHEMBL871418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-ABL
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.14 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210827 | — | — | 1 | 8.52 |
| CHEMBL209753 | — | — | 1 | 8.15 |
| CHEMBL376945 | — | — | 1 | 8.00 |
| CHEMBL211508 | — | — | 1 | 7.70 |
| CHEMBL211662 | — | — | 1 | 7.52 |
| CHEMBL378024 | — | — | 1 | 7.52 |
| CHEMBL379987 | — | — | 1 | 7.22 |
| CHEMBL377346 | — | — | 1 | 7.22 |
| CHEMBL211154 | — | — | 1 | 7.22 |
| CHEMBL384213 | — | — | 1 | 6.89 |
| CHEMBL377463 | — | — | 1 | 6.82 |
| CHEMBL209704 | — | — | 1 | 6.70 |
| CHEMBL209266 | — | — | 1 | 6.66 |
| CHEMBL209305 | — | — | 1 | 6.64 |
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 6.37 |
| CHEMBL378299 | — | — | 1 | 6.22 |
| CHEMBL212673 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210827 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL209753 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL376945 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL211508 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL211662 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL378024 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL379987 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL377346 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL211154 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL384213 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL377463 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL209704 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL209266 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL209305 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1642 | IMATINIB MESYLATE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL378299 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL212673 | — | IC50 | = | 900.0 | nM | 6.05 |