Assay Detail
Binding
CHEMBL871476
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Inhibition of Torpedo californica AChE
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.24 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539874 | GENESERINE | — | 1 | 5.76 |
| CHEMBL539623 | — | — | 1 | 5.39 |
| CHEMBL541663 | — | — | 1 | 5.32 |
| CHEMBL538602 | — | — | 1 | 5.29 |
| CHEMBL539624 | — | — | 1 | 5.29 |
| CHEMBL556603 | — | — | 1 | 5.12 |
| CHEMBL558409 | — | — | 1 | 5.08 |
| CHEMBL539875 | — | — | 1 | 5.07 |
| CHEMBL539625 | — | — | 1 | 5.07 |
| CHEMBL539873 | — | — | 1 | 5.01 |
| CHEMBL538603 | — | — | 1 | - |
| CHEMBL1201092 | RIVASTIGMINE TARTRATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539874 | GENESERINE | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL539623 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL541663 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL538602 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL539624 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL556603 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL558409 | — | IC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL539875 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL539625 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL539873 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL538603 | — | IC50 | = | 186000.0 | nM | - |
| CHEMBL1201092 | RIVASTIGMINE TARTRATE | IC50 | = | 187200.0 | nM | - |