Assay Detail
Binding
CHEMBL871583
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Inhibition of human PI3Kalpha
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | — | 1 | 9.00 |
| CHEMBL211819 | — | — | 1 | 7.00 |
| CHEMBL378528 | — | — | 1 | 6.73 |
| CHEMBL211173 | — | — | 1 | 6.72 |
| CHEMBL377152 | — | — | 1 | 6.68 |
| CHEMBL378999 | — | — | 1 | 6.66 |
| CHEMBL208652 | — | — | 1 | 6.48 |
| CHEMBL209159 | — | — | 1 | 6.47 |
| CHEMBL377175 | — | — | 1 | 6.34 |
| CHEMBL377104 | — | — | 1 | 6.30 |
| CHEMBL212119 | — | — | 1 | 6.26 |
| CHEMBL437688 | — | — | 1 | 6.22 |
| CHEMBL211768 | — | — | 1 | 6.22 |
| CHEMBL376984 | — | — | 1 | 6.20 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.14 |
| CHEMBL379156 | — | — | 1 | 6.03 |
| CHEMBL211068 | — | — | 1 | 6.00 |
| CHEMBL210991 | — | — | 1 | 5.90 |
| CHEMBL208696 | — | — | 1 | 5.87 |
| CHEMBL208662 | — | — | 1 | 5.75 |
| CHEMBL211759 | — | — | 1 | 5.44 |
| CHEMBL209193 | — | — | 1 | 4.70 |
| CHEMBL208697 | — | — | 1 | - |
| CHEMBL427402 | — | — | 1 | - |
| CHEMBL209040 | — | — | 1 | - |
| CHEMBL208699 | — | — | 1 | - |
| CHEMBL378107 | — | — | 1 | - |
| CHEMBL208977 | — | — | 1 | - |
| CHEMBL209194 | — | — | 1 | - |
| CHEMBL377337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL211819 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL378528 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL211173 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL377152 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL378999 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL208652 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL209159 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL377175 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL377104 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL212119 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL437688 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL211768 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL376984 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL98350 | LY-294002 | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL379156 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL211068 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL210991 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL208696 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL208662 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL211759 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL209193 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL208697 | — | IC50 | - | — | - | |
| CHEMBL427402 | — | IC50 | - | — | - | |
| CHEMBL209040 | — | IC50 | - | — | - | |
| CHEMBL208699 | — | IC50 | - | — | - | |
| CHEMBL378107 | — | IC50 | - | — | - | |
| CHEMBL208977 | — | IC50 | - | — | - | |
| CHEMBL209194 | — | IC50 | - | — | - | |
| CHEMBL377337 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL208698 | — | IC50 | - | — | - |