Assay Detail
Binding
CHEMBL871627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 15 pM [125I]MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.98 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197050 | — | — | 1 | 9.05 |
| CHEMBL370120 | — | — | 1 | 9.04 |
| CHEMBL197026 | — | — | 1 | 8.82 |
| CHEMBL195635 | — | — | 1 | 8.82 |
| CHEMBL198361 | — | — | 1 | 8.80 |
| CHEMBL427540 | — | — | 1 | 8.72 |
| CHEMBL197245 | — | — | 1 | 8.68 |
| CHEMBL184084 | — | — | 1 | 8.64 |
| CHEMBL196567 | — | — | 1 | 8.64 |
| CHEMBL194459 | — | — | 1 | 8.64 |
| CHEMBL196581 | — | — | 1 | 8.57 |
| CHEMBL196196 | — | — | 1 | 8.52 |
| CHEMBL195351 | — | — | 1 | 8.40 |
| CHEMBL194046 | — | — | 1 | 8.37 |
| CHEMBL196667 | — | — | 1 | 8.30 |
| CHEMBL196091 | — | — | 1 | 8.26 |
| CHEMBL194408 | — | — | 1 | 8.23 |
| CHEMBL373084 | — | — | 1 | 8.21 |
| CHEMBL193473 | — | — | 1 | 8.21 |
| CHEMBL187756 | — | — | 1 | 8.19 |
| CHEMBL194691 | — | — | 1 | 8.06 |
| CHEMBL189118 | — | — | 1 | 7.80 |
| CHEMBL194477 | — | — | 1 | 7.70 |
| CHEMBL197145 | — | — | 1 | 7.54 |
| CHEMBL435494 | — | — | 1 | 7.54 |
| CHEMBL196627 | — | — | 1 | 7.30 |
| CHEMBL194837 | — | — | 1 | 7.07 |
| CHEMBL195250 | — | — | 1 | 7.00 |
| CHEMBL195022 | — | — | 1 | 6.96 |
| CHEMBL382755 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197050 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL370120 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL197026 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL195635 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL198361 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL427540 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL197245 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL184084 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL196567 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL194459 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL196581 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL196196 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL195351 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL194046 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL196667 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL196091 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL194408 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL373084 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL193473 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL187756 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL194691 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL189118 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL194477 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL197145 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL435494 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL196627 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL194837 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL195250 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL195022 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL382755 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL370820 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL196360 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL194484 | — | IC50 | = | 5360.0 | nM | 5.27 |