Compound Detail
CHEMBL193473
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL193473 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RFQAEWCPAAHVMT-BJMVGYQFSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
470.5
MW (Da)
4.89
ALogP
5
HBA
2
HBD
66.5
PSA (Ų)
0.52
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 8.21 | 7.68 | 6.1 | 3 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 6.1 | nM | 8.21 | Displacement of 15 pM [125I]MCH from human MCH1R expressed in CHO-K1 in whole-ce... | 16134937 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 23.0 | nM | 7.64 | Displacement of 150p M [125I]MCH from human MCH1R expressed in CHO-K1 cells | 16134937 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 65.0 | nM | 7.19 | Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 ce... | 16134937 |
| 5-hydroxytryptamine receptor 2C | IC50 | = | 1600.0 | nM | 5.8 | Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed... | 16134937 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16134937 | 10.1021/jm050103y | Melanin-concentrating hormone receptor 1 | 3 |
| 16134937 | 10.1021/jm050103y | 5-hydroxytryptamine receptor 2C | 1 |
Data from ChEMBL 36 via Core Engine