Assay Detail
Binding
CHEMBL881790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]mesulergine
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.58 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187756 | — | — | 1 | 6.21 |
| CHEMBL373084 | — | — | 1 | 6.11 |
| CHEMBL195351 | — | — | 1 | 5.96 |
| CHEMBL193473 | — | — | 1 | 5.80 |
| CHEMBL196667 | — | — | 1 | 5.70 |
| CHEMBL194837 | — | — | 2 | 5.60 |
| CHEMBL196581 | — | — | 1 | 5.40 |
| CHEMBL194691 | — | — | 1 | 5.33 |
| CHEMBL196196 | — | — | 1 | 5.24 |
| CHEMBL197245 | — | — | 1 | 5.23 |
| CHEMBL194046 | — | — | 1 | 4.75 |
| CHEMBL198361 | — | — | 1 | - |
| CHEMBL197050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187756 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL373084 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL195351 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL193473 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL196667 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL194837 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL194837 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL196581 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL194691 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL196196 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL197245 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL194046 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL198361 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL197050 | — | IC50 | > | 10000.0 | nM | - |