Assay Detail
Functional
CHEMBL884193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]myo-inositol
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.41 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197050 | — | — | 1 | 8.28 |
| CHEMBL195635 | — | — | 1 | 8.12 |
| CHEMBL197245 | — | — | 1 | 7.96 |
| CHEMBL198361 | — | — | 1 | 7.92 |
| CHEMBL196567 | — | — | 1 | 7.85 |
| CHEMBL197026 | — | — | 1 | 7.85 |
| CHEMBL196091 | — | — | 1 | 7.81 |
| CHEMBL427540 | — | — | 1 | 7.80 |
| CHEMBL196581 | — | — | 1 | 7.80 |
| CHEMBL370120 | — | — | 1 | 7.72 |
| CHEMBL184084 | — | — | 1 | 7.60 |
| CHEMBL373084 | — | — | 1 | 7.55 |
| CHEMBL196196 | — | — | 1 | 7.38 |
| CHEMBL193473 | — | — | 1 | 7.19 |
| CHEMBL194408 | — | — | 1 | 7.18 |
| CHEMBL196667 | — | — | 1 | 7.13 |
| CHEMBL195351 | — | — | 1 | 7.06 |
| CHEMBL187756 | — | — | 1 | 7.05 |
| CHEMBL194046 | — | — | 1 | 7.01 |
| CHEMBL194691 | — | — | 1 | 6.96 |
| CHEMBL195250 | — | — | 1 | 5.94 |
| CHEMBL194837 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197050 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL195635 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL197245 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL198361 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL196567 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL197026 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL196091 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL427540 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL196581 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL370120 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL184084 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL373084 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL196196 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL193473 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL194408 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL196667 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL195351 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL187756 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL194046 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL194691 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL195250 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL194837 | — | IC50 | = | 1480.0 | nM | 5.83 |