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Assay Detail

CHEMBL871692

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity measured on wild-type P388 murine leukemia cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Autocuration

Publication

Potential antitumor agents. 64. Synthesis and antitumor evaluation of dibenzo[1,4]dioxin-1-carboxamides: a new class of weakly binding DNA-intercalating agents.
Lee HH, Palmer BD, Boyd M, Baguley BC, Denny WA.
J Med Chem (1992) 35 : 258 -266
PubMed 1310119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.87 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90047 1 7.50
CHEMBL88852 1 6.68
CHEMBL89783 1 6.64
CHEMBL89593 1 6.60
CHEMBL89850 1 6.42
CHEMBL88613 1 6.14
CHEMBL88802 1 6.08
CHEMBL424428 1 5.89
CHEMBL92536 1 5.80
CHEMBL88714 1 5.80
CHEMBL314468 1 5.77
CHEMBL90551 1 5.72
CHEMBL88226 1 5.68
CHEMBL419309 1 5.60
CHEMBL88776 1 5.52
CHEMBL89722 1 5.52
CHEMBL88888 1 5.48
CHEMBL315656 1 5.43
CHEMBL88777 1 5.29
CHEMBL88315 1 5.24
CHEMBL91426 1 5.22
CHEMBL92435 1 5.10
CHEMBL88753 1 -
CHEMBL88215 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90047 IC50 = 32.0 nM 7.50
CHEMBL88852 IC50 = 210.0 nM 6.68
CHEMBL89783 IC50 = 230.0 nM 6.64
CHEMBL89593 IC50 = 250.0 nM 6.60
CHEMBL89850 IC50 = 380.0 nM 6.42
CHEMBL88613 IC50 = 720.0 nM 6.14
CHEMBL88802 IC50 = 830.0 nM 6.08
CHEMBL424428 IC50 = 1300.0 nM 5.89
CHEMBL92536 IC50 = 1600.0 nM 5.80
CHEMBL88714 IC50 = 1600.0 nM 5.80
CHEMBL314468 IC50 = 1700.0 nM 5.77
CHEMBL90551 IC50 = 1900.0 nM 5.72
CHEMBL88226 IC50 = 2100.0 nM 5.68
CHEMBL419309 IC50 = 2500.0 nM 5.60
CHEMBL88776 IC50 = 3000.0 nM 5.52
CHEMBL89722 IC50 = 3000.0 nM 5.52
CHEMBL88888 IC50 = 3300.0 nM 5.48
CHEMBL315656 IC50 = 3700.0 nM 5.43
CHEMBL88777 IC50 = 5130.0 nM 5.29
CHEMBL88315 IC50 = 5800.0 nM 5.24
CHEMBL91426 IC50 = 6000.0 nM 5.22
CHEMBL92435 IC50 = 8000.0 nM 5.10
CHEMBL88753 IC50 > 10000.0 nM -
CHEMBL88215 IC50 > 20000.0 nM -