Assay Detail
Binding
CHEMBL871845
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Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phosphatidylserine
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.22 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137386 | — | — | 1 | 9.05 |
| CHEMBL370130 | — | — | 1 | 8.50 |
| CHEMBL434938 | — | — | 1 | 7.69 |
| CHEMBL194257 | — | — | 1 | 6.66 |
| CHEMBL363418 | — | — | 1 | 5.72 |
| CHEMBL194357 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137386 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL370130 | — | Ki | = | 3.13 | nM | 8.50 |
| CHEMBL434938 | — | Ki | = | 20.6 | nM | 7.69 |
| CHEMBL194257 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL363418 | — | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL194357 | — | Ki | = | 2140.0 | nM | 5.67 |