Compound Detail
CHEMBL194257
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Basic Information
| ChEMBL ID | CHEMBL194257 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZZNLNGDYKWBALR-DJKKODMXSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
368.6
MW (Da)
4.75
ALogP
4
HBA
1
HBD
55.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C delta type CHEMBL2996 | Ki | 6.66 | 5.92 | 219.0 | 2 |
| Protein kinase C alpha type CHEMBL299 | Ki | 6.21 | 6.21 | 622.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C delta type | Ki | = | 219.0 | nM | 6.66 | Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phos... | 16134942 |
| Protein kinase C alpha type | Ki | = | 622.0 | nM | 6.21 | Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determi... | 16134942 |
| Protein kinase C delta type | Ki | = | 6620.0 | nM | 5.18 | Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C delta without ... | 16134942 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16134942 | 10.1021/jm050352m | Protein kinase C delta type | 2 |
| 16134942 | 10.1021/jm050352m | Protein kinase C alpha type | 1 |
Data from ChEMBL 36 via Core Engine