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Assay Detail

CHEMBL871886

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours
43
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Expert

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Analogues of thiolactomycin as potential antimalarial agents.
Jones SM, Urch JE, Kaiser M, Brun R, Harwood JL, Berry C, Gilbert IH.
J Med Chem (2005) 48 : 5932 -5941
PubMed 16161997 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 4.62 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371411 1 5.70
CHEMBL196163 1 5.22
CHEMBL370373 1 5.16
CHEMBL197941 1 5.10
CHEMBL197258 1 5.05
CHEMBL197886 1 5.05
CHEMBL198280 1 4.89
CHEMBL366184 1 4.85
CHEMBL371919 1 4.68
CHEMBL194317 1 4.54
CHEMBL427000 1 4.50
CHEMBL197928 1 4.33
CHEMBL197622 1 4.26
CHEMBL382314 1 4.21
CHEMBL194977 1 4.21
CHEMBL370442 1 4.19
CHEMBL196053 1 4.19
CHEMBL196061 1 4.15
CHEMBL198195 1 4.10
CHEMBL198418 1 4.01
CHEMBL194456 1 -
CHEMBL197835 1 -
CHEMBL383559 1 -
CHEMBL194262 1 -
CHEMBL197925 1 -
CHEMBL198051 1 -
CHEMBL382275 1 -
CHEMBL198765 1 -
CHEMBL370574 1 -
CHEMBL371378 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371411 IC50 = 2000.0 nM 5.70
CHEMBL196163 IC50 = 6000.0 nM 5.22
CHEMBL370373 IC50 = 7000.0 nM 5.16
CHEMBL197941 IC50 = 8000.0 nM 5.10
CHEMBL197258 IC50 = 9000.0 nM 5.05
CHEMBL197886 IC50 = 9000.0 nM 5.05
CHEMBL198280 IC50 = 13000.0 nM 4.89
CHEMBL366184 IC50 = 14000.0 nM 4.85
CHEMBL371919 IC50 = 21000.0 nM 4.68
CHEMBL194317 IC50 = 29000.0 nM 4.54
CHEMBL427000 IC50 = 32000.0 nM 4.50
CHEMBL197928 IC50 = 47000.0 nM 4.33
CHEMBL197622 IC50 = 55000.0 nM 4.26
CHEMBL194977 IC50 = 62000.0 nM 4.21
CHEMBL382314 IC50 = 62000.0 nM 4.21
CHEMBL196053 IC50 = 64000.0 nM 4.19
CHEMBL370442 IC50 = 64000.0 nM 4.19
CHEMBL196061 IC50 = 71000.0 nM 4.15
CHEMBL198195 IC50 = 79000.0 nM 4.10
CHEMBL198418 IC50 = 97000.0 nM 4.01
CHEMBL381463 IC50 = 171000.0 nM -
CHEMBL196776 IC50 = 194000.0 nM -
CHEMBL196418 IC50 = 256000.0 nM -
CHEMBL198765 IC50 = 157000.0 nM -
CHEMBL193803 IC50 = 112000.0 nM -
CHEMBL193965 IC50 = 408000.0 nM -
CHEMBL371378 IC50 = 132000.0 nM -
CHEMBL370574 IC50 > 568000.0 nM -
CHEMBL196952 IC50 = 288000.0 nM -
CHEMBL382275 IC50 = 153000.0 nM -
CHEMBL197346 IC50 = 190000.0 nM -
CHEMBL370428 IC50 = 357000.0 nM -
CHEMBL197835 IC50 = 157000.0 nM -
CHEMBL196358 THIOLACTONE IC50 > 624000.0 nM -
CHEMBL196112 IC50 = 119000.0 nM -
CHEMBL194456 IC50 > 200000.0 nM -
CHEMBL383559 IC50 = 167000.0 nM -
CHEMBL381862 IC50 = 247000.0 nM -
CHEMBL194262 IC50 > 223000.0 nM -
CHEMBL196874 IC50 > 633000.0 nM -
CHEMBL197925 IC50 = 149000.0 nM -
CHEMBL196418 IC50 = 182000.0 nM -
CHEMBL198051 IC50 = 130000.0 nM -