Assay Detail
Functional
CHEMBL871939
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Cytotoxicity against H 358 human lung cancer cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H358 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-methylcarbamate derivatives of ellipticine and olivacine with cytotoxic activity against four human lung cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.30 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144698 | — | — | 1 | 7.05 |
| CHEMBL142232 | — | — | 1 | 7.00 |
| CHEMBL144606 | — | — | 1 | 6.96 |
| CHEMBL19569 | — | — | 1 | 6.72 |
| CHEMBL144783 | — | — | 1 | 5.89 |
| CHEMBL142242 | — | — | 1 | 5.82 |
| CHEMBL145377 | — | — | 1 | 5.70 |
| CHEMBL26559 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144698 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL142232 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL144606 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL19569 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL144783 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL142242 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL145377 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL26559 | — | IC50 | = | 5600.0 | nM | 5.25 |