Assay Detail
Binding
CHEMBL871941
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In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Potassium-transporting ATPase alpha chain 1 (CHEMBL3919) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.82 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47529 | — | — | 1 | 7.00 |
| CHEMBL358421 | — | — | 1 | 6.77 |
| CHEMBL346188 | — | — | 1 | 6.39 |
| CHEMBL357193 | — | — | 1 | 6.38 |
| CHEMBL440726 | — | — | 1 | 6.28 |
| CHEMBL298695 | — | — | 1 | 6.19 |
| CHEMBL151251 | — | — | 1 | 6.18 |
| CHEMBL357596 | — | — | 1 | 6.12 |
| CHEMBL95108 | — | — | 1 | 6.07 |
| CHEMBL357510 | — | — | 1 | 6.00 |
| CHEMBL153811 | — | — | 1 | 5.96 |
| CHEMBL356892 | — | — | 1 | 5.89 |
| CHEMBL149052 | — | — | 1 | 5.82 |
| CHEMBL147246 | — | — | 1 | 5.80 |
| CHEMBL151252 | — | — | 1 | 5.62 |
| CHEMBL449033 | — | — | 1 | 5.54 |
| CHEMBL146903 | — | — | 1 | 5.51 |
| CHEMBL357274 | — | — | 1 | 5.01 |
| CHEMBL151290 | — | — | 1 | 4.96 |
| CHEMBL356246 | — | — | 1 | 4.66 |
| CHEMBL443295 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47529 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL358421 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL346188 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL357193 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL440726 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL298695 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL151251 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL357596 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL95108 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL357510 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL153811 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL356892 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL149052 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL147246 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL151252 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL449033 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL146903 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL357274 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL151290 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL356246 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL443295 | — | IC50 | = | 69000.0 | nM | 4.16 |