Assay Detail
Functional
CHEMBL872003
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Antiproliferative activity assessed in the RENCA murine renal cell carcinoma using the BrdU
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | renal |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.30 |
| CHEMBL541365 | — | — | 1 | 6.16 |
| CHEMBL544639 | — | — | 2 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL541365 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL544639 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL544639 | — | IC50 | = | 1000.0 | nM | 6.00 |