Assay Detail
Functional
CHEMBL872008
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In vitro inhibition of serotonin (5-HT) uptake in crude rat brain synaptosomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.49 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94739 | FEMOXETINE | 2.0 | 1 | 8.08 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 7.22 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 7.16 |
| CHEMBL288524 | — | — | 1 | 7.02 |
| CHEMBL55822 | — | — | 1 | 6.17 |
| CHEMBL36591 | ALAPROCLATE | 2.0 | 1 | 6.16 |
| CHEMBL55093 | — | — | 1 | 6.08 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 5.82 |
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 5.70 |
| CHEMBL56675 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94739 | FEMOXETINE | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL809 | SERTRALINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL288524 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL55822 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL36591 | ALAPROCLATE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL55093 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL295467 | NISOXETINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL56675 | — | IC50 | = | 3000.0 | nM | 5.52 |