Assay Detail
Functional
CHEMBL872010
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Compound was evaluated for the inhibition of K+ -evoked glutamate release through block of voltage-gated [Ca2+] -channels, in the rat brain synaptosomal preparations
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.05 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307395 | — | — | 1 | 6.10 |
| CHEMBL28853 | — | — | 1 | 6.00 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307395 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL28853 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL744 | RILUZOLE | IC50 | = | - | nM | - |