Assay Detail
Functional
CHEMBL872012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of release of histamine in rat passive peritoneal anaphylaxis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy) [1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.02 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420567 | — | — | 1 | 7.00 |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | 6.13 |
| CHEMBL308791 | — | — | 1 | 6.08 |
| CHEMBL312083 | — | — | 1 | 6.05 |
| CHEMBL420934 | — | — | 1 | 6.00 |
| CHEMBL74989 | — | — | 1 | 5.64 |
| CHEMBL74870 | — | — | 1 | 5.27 |
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | - |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420567 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL74 | CROMOLYN SODIUM | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL308791 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL312083 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL420934 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL74989 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL74870 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL534 | KETOTIFEN | IC50 | > | 200000.0 | nM | - |
| CHEMBL511 | PYRILAMINE | IC50 | > | 200000.0 | nM | - |