Assay Detail
Functional
CHEMBL872034
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Inhibitory concentration against [3H]- DA uptake in crude rat synaptosomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.60 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 5.87 |
| CHEMBL6842 | — | — | 1 | 5.73 |
| CHEMBL331488 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6731 | TENAMFETAMINE | IC50 | = | 1356.0 | nM | 5.87 |
| CHEMBL6842 | — | IC50 | = | 1847.0 | nM | 5.73 |
| CHEMBL331488 | — | IC50 | = | 6436.0 | nM | 5.19 |