Assay Detail
Binding
CHEMBL872286
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Binding affinity for human p38 MAP kinase expressed in Escherichia coli using [gamma-33P]ATP; n=4
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 9.23 | 10.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194813 | — | — | 1 | 10.33 |
| CHEMBL363643 | — | — | 1 | 10.30 |
| CHEMBL196741 | — | — | 1 | 10.24 |
| CHEMBL197206 | — | — | 1 | 10.24 |
| CHEMBL195532 | — | — | 1 | 9.82 |
| CHEMBL197351 | — | — | 1 | 9.80 |
| CHEMBL274257 | — | — | 2 | 9.39 |
| CHEMBL198876 | — | — | 1 | 9.39 |
| CHEMBL382954 | — | — | 1 | 9.21 |
| CHEMBL383137 | — | — | 1 | 9.01 |
| CHEMBL370783 | — | — | 1 | 8.82 |
| CHEMBL383172 | — | — | 1 | 8.80 |
| CHEMBL198872 | — | — | 1 | 8.72 |
| CHEMBL198456 | — | — | 1 | 7.85 |
| CHEMBL196230 | — | — | 1 | 7.82 |
| CHEMBL198198 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194813 | — | Ki | = | 0.047 | nM | 10.33 |
| CHEMBL363643 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL196741 | — | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL197206 | — | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL195532 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL197351 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL274257 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL198876 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL274257 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL382954 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL383137 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL370783 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL383172 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL198872 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL198456 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL196230 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL198198 | — | Ki | = | 16.0 | nM | 7.80 |