Assay Detail
Binding
CHEMBL872297
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Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase catalytic subunit (CHEMBL4859) ↗| Type | SINGLE PROTEIN |
| Organism | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
Publication
4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.00 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363625 | — | — | 2 | 7.16 |
| CHEMBL194433 | — | — | 2 | 6.43 |
| CHEMBL195453 | — | — | 2 | 6.34 |
| CHEMBL29711 | APHIDICOLIN | — | 2 | 6.22 |
| CHEMBL440033 | — | — | 2 | 6.11 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 2 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363625 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL194433 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL195453 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL440033 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL195453 | — | IC50 | - | nM | - | |
| CHEMBL440033 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL363625 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL194433 | — | IC50 | > | 40000.0 | nM | - |