Assay Detail

CHEMBL872357

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Binding

Affinity towards cloned human 5-hydroxytryptamine 1D receptor

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 1D (CHEMBL1983) ↗

Open DB target context

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5-hydroxytryptamine receptor 1D (CHEMBL1983) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 1D

CHEMBL1983

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 1D

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

5-hydroxytryptamine receptor 1D (CHEMBL1983) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis of potent and selective serotonin 5-HT1B receptor ligands.

Huang Y, Bae SA, Roth BL, Laruelle M.
Bioorg Med Chem Lett (2005) 15 : 4786 -4789
PubMed 16143528 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.15	9.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL15928	GR-127935	—	1	9.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL15928	GR-127935	Ki	=	0.7	nM	9.15