Assay Detail
Binding
CHEMBL872360
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Binding affinity for mGluR1 receptor expressed in CHO cells
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 1 (CHEMBL4477) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.28 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194787 | — | — | 2 | 4.57 |
| CHEMBL198310 | — | — | 1 | 4.48 |
| CHEMBL421402 | — | — | 1 | 4.02 |
| CHEMBL415461 | — | — | 1 | - |
| CHEMBL197629 | — | — | 2 | - |
| CHEMBL322887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194787 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL198310 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL194787 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL421402 | — | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL415461 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL197629 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL197629 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL322887 | — | Ki | > | 1000000.0 | nM | - |