Assay Detail
Binding
CHEMBL872386
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In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.17 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372453 | — | — | 1 | 8.19 |
| CHEMBL15928 | GR-127935 | — | 1 | 7.91 |
| CHEMBL195927 | — | — | 1 | 7.81 |
| CHEMBL370128 | — | — | 1 | 7.46 |
| CHEMBL196169 | — | — | 1 | 6.99 |
| CHEMBL196370 | — | — | 1 | 6.97 |
| CHEMBL194206 | — | — | 1 | 6.77 |
| CHEMBL197408 | — | — | 1 | 6.68 |
| CHEMBL197796 | — | — | 1 | 6.48 |
| CHEMBL196598 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372453 | — | Ki | = | 6.51 | nM | 8.19 |
| CHEMBL15928 | GR-127935 | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL195927 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL370128 | — | Ki | = | 34.7 | nM | 7.46 |
| CHEMBL196169 | — | Ki | = | 103.1 | nM | 6.99 |
| CHEMBL196370 | — | Ki | = | 105.9 | nM | 6.97 |
| CHEMBL194206 | — | Ki | = | 168.2 | nM | 6.77 |
| CHEMBL197408 | — | Ki | = | 209.2 | nM | 6.68 |
| CHEMBL197796 | — | Ki | = | 328.7 | nM | 6.48 |
| CHEMBL196598 | — | Ki | = | 345.1 | nM | 6.46 |