Assay Detail
Binding
CHEMBL872437
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NK3 IC50 determined using [125I]bolton Hunter labeled eledoisin at NK3 receptors from guinea pig cerebral cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.18 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330366 | — | — | 1 | 7.68 |
| CHEMBL308148 | SAREDUTANT | 3.0 | 1 | 6.68 |
| CHEMBL16192 | CP-96345 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330366 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL308148 | SAREDUTANT | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL16192 | CP-96345 | IC50 | > | 10000.0 | nM | - |