Assay Detail
Binding
CHEMBL872473
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Inhibition of Human Cathepsin K
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.13 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028910 | — | — | 1 | 9.74 |
| CHEMBL2028921 | — | — | 1 | 9.07 |
| CHEMBL2028911 | — | — | 1 | 8.67 |
| CHEMBL2028909 | — | — | 1 | 8.67 |
| CHEMBL2028919 | — | — | 1 | 8.61 |
| CHEMBL2028920 | — | — | 1 | 8.24 |
| CHEMBL2028908 | — | — | 1 | 8.17 |
| CHEMBL2028912 | — | — | 1 | 8.07 |
| CHEMBL2028907 | — | — | 1 | 7.68 |
| CHEMBL3143135 | — | — | 1 | 7.47 |
| CHEMBL3143130 | — | — | 1 | 7.21 |
| CHEMBL2028906 | — | — | 1 | 7.14 |
| CHEMBL2028913 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028910 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL2028921 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL2028911 | — | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL2028909 | — | Ki | = | 2.13 | nM | 8.67 |
| CHEMBL2028919 | — | Ki | = | 2.45 | nM | 8.61 |
| CHEMBL2028920 | — | Ki | = | 5.75 | nM | 8.24 |
| CHEMBL2028908 | — | Ki | = | 6.76 | nM | 8.17 |
| CHEMBL2028912 | — | Ki | = | 8.42 | nM | 8.07 |
| CHEMBL2028907 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3143135 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3143130 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2028906 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL2028913 | — | Ki | = | 100.0 | nM | 7.00 |