Assay Detail
Binding
CHEMBL872477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Coagulation factor X
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.37 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174558 | — | — | 1 | 10.00 |
| CHEMBL369681 | — | — | 1 | 9.70 |
| CHEMBL175130 | — | — | 1 | 9.52 |
| CHEMBL172360 | — | — | 1 | 9.30 |
| CHEMBL176243 | — | — | 1 | 9.22 |
| CHEMBL174499 | — | — | 1 | 9.00 |
| CHEMBL367953 | — | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174558 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL369681 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL175130 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL172360 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL176243 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL174499 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL367953 | — | Ki | = | 1.5 | nM | 8.82 |