Assay Detail
Binding
CHEMBL872489
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Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.36 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.37 |
| CHEMBL144114 | — | — | 1 | 4.22 |
| CHEMBL341825 | — | — | 1 | 4.22 |
| CHEMBL144501 | — | — | 1 | 4.01 |
| CHEMBL144302 | — | — | 1 | 4.00 |
| CHEMBL280491 | — | — | 1 | - |
| CHEMBL72630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL144114 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL341825 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL144501 | — | Ki | = | 98000.0 | nM | 4.01 |
| CHEMBL144302 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL280491 | — | Ki | = | 112000.0 | nM | - |
| CHEMBL72630 | — | Ki | = | 102000.0 | nM | - |