Assay Detail
Binding
CHEMBL872563
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Inhibition of human recombinant matrix metalloprotease 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.53 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56837 | — | — | 1 | 8.28 |
| CHEMBL61193 | — | — | 1 | 8.10 |
| CHEMBL57644 | — | — | 1 | 7.58 |
| CHEMBL43087 | — | — | 1 | 6.89 |
| CHEMBL60536 | — | — | 1 | 6.79 |
| CHEMBL58577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56837 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL61193 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL57644 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL43087 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL60536 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL58577 | — | Ki | > | 850.0 | nM | - |