Assay Detail
Binding
CHEMBL872576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Vasopressin V2 receptor was determined in Brattleboro rats
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-isopropylacetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.62 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340893 | — | — | 1 | 6.82 |
| CHEMBL332447 | — | — | 1 | 6.64 |
| CHEMBL125878 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340893 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL332447 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL125878 | — | IC50 | = | 390.0 | nM | 6.41 |