Assay Detail
Binding
CHEMBL872600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for its ability to inhibit serine protease thrombin using succinyl-Ala-p-nitroanilide as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.42 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41876 | — | — | 1 | 8.34 |
| CHEMBL289951 | — | — | 1 | 7.96 |
| CHEMBL287807 | — | — | 1 | 7.89 |
| CHEMBL291062 | — | — | 1 | 7.48 |
| CHEMBL282549 | — | — | 1 | 7.16 |
| CHEMBL287910 | — | — | 1 | 6.58 |
| CHEMBL41862 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41876 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL289951 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL287807 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL291062 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL282549 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL287910 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL41862 | — | Ki | = | 320.0 | nM | 6.50 |