Assay Detail
Binding
CHEMBL872641
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Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.32 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 9.68 |
| CHEMBL444832 | — | — | 1 | 7.80 |
| CHEMBL296014 | — | — | 1 | 7.40 |
| CHEMBL48731 | — | — | 1 | 5.92 |
| CHEMBL33650 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL444832 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL296014 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL48731 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL33650 | — | IC50 | = | 1500.0 | nM | 5.82 |