Assay Detail
Functional
CHEMBL872644
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Inhibition of Toxoplasma gondii tachyzoites in human foreskin fibroblast monolayer(DMEM with 10%fetal calf serum)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.00 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 6.31 |
| CHEMBL434024 | — | — | 1 | 5.04 |
| CHEMBL52761 | — | — | 1 | 5.04 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 4.45 |
| CHEMBL417932 | — | — | 1 | 4.17 |
| CHEMBL55886 | — | — | 1 | - |
| CHEMBL293522 | — | — | 1 | - |
| CHEMBL298771 | — | — | 1 | - |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL434024 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL52761 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL417932 | — | IC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL55886 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL293522 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL298771 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 147000.0 | nM | - |