Assay Detail
Binding
CHEMBL872663
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Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
PD 165929 the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.97 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437027 | BOMBESIN | 1.0 | 1 | 8.70 |
| CHEMBL269432 | — | — | 1 | 8.68 |
| CHEMBL86828 | — | — | 1 | 8.20 |
| CHEMBL329561 | — | — | 1 | 8.11 |
| CHEMBL1907865 | — | — | 1 | 7.85 |
| CHEMBL315859 | — | — | 1 | 7.14 |
| CHEMBL1907682 | — | — | 1 | 7.12 |
| CHEMBL89075 | — | — | 1 | 7.02 |
| CHEMBL315660 | — | — | 1 | 6.92 |
| CHEMBL89153 | — | — | 1 | 6.90 |
| CHEMBL88174 | — | — | 1 | 6.58 |
| CHEMBL87090 | — | — | 1 | 6.51 |
| CHEMBL89795 | — | — | 1 | 6.51 |
| CHEMBL406037 | — | — | 1 | 6.38 |
| CHEMBL312851 | — | — | 1 | 6.36 |
| CHEMBL313829 | — | — | 1 | 6.35 |
| CHEMBL328230 | — | — | 1 | 6.31 |
| CHEMBL92274 | — | — | 1 | 6.20 |
| CHEMBL328591 | — | — | 1 | 6.12 |
| CHEMBL313114 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437027 | BOMBESIN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL269432 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL86828 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL329561 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL1907865 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL315859 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL1907682 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL89075 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL315660 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL89153 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL88174 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL87090 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL89795 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL406037 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL312851 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL313829 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL328230 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL92274 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL328591 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL313114 | — | Ki | = | 3700.0 | nM | 5.43 |