Assay Detail
Functional
CHEMBL872678
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In vitro cytotoxic activity was evaluated using the human uterine sarcoma cell line MES-SA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of a new potent daunomycinone derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.31 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.60 |
| CHEMBL119012 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL119012 | — | IC50 | = | 7000.0 | nM | 5.16 |