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Assay Detail

CHEMBL872687

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Binding
Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Methionine aminopeptidase (CHEMBL3423) ↗
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.
Luo QL, Li JY, Liu ZY, Chen LL, Li J, Qian Z, Shen Q, Li Y, Lushington GH, Ye QZ, Nan FJ.
J Med Chem (2003) 46 : 2631 -2640
PubMed 12801227 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.02 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90048 — — 1 6.89
CHEMBL90049 — — 1 6.82
CHEMBL327579 — — 1 6.75
CHEMBL313629 — — 1 6.66
CHEMBL328350 — — 1 6.62
CHEMBL92374 — — 1 6.58
CHEMBL446935 — — 1 6.55
CHEMBL313915 — — 1 6.55
CHEMBL91372 — — 1 6.48
CHEMBL328555 — — 1 6.47
CHEMBL313650 — — 1 6.42
CHEMBL90827 — — 1 6.40
CHEMBL316308 — — 1 6.27
CHEMBL86427 — — 1 6.27
CHEMBL89687 — — 1 6.22
CHEMBL89612 — — 1 6.21
CHEMBL89386 — — 1 6.17
CHEMBL316138 — — 1 6.15
CHEMBL313951 — — 1 6.08
CHEMBL329455 — — 1 6.06
CHEMBL89609 — — 1 6.05
CHEMBL88489 — — 1 6.02
CHEMBL315903 — — 1 5.99
CHEMBL91437 — — 1 5.96
CHEMBL315270 — — 1 5.91
CHEMBL90619 — — 1 5.89
CHEMBL329320 — — 1 5.87
CHEMBL420981 — — 1 5.80
CHEMBL314521 — — 1 5.77
CHEMBL88599 — — 1 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90048 — IC50 = 130.0 nM 6.89
CHEMBL90049 — IC50 = 150.0 nM 6.82
CHEMBL327579 — IC50 = 180.0 nM 6.75
CHEMBL313629 — IC50 = 220.0 nM 6.66
CHEMBL328350 — IC50 = 240.0 nM 6.62
CHEMBL92374 — IC50 = 260.0 nM 6.58
CHEMBL446935 — IC50 = 280.0 nM 6.55
CHEMBL313915 — IC50 = 280.0 nM 6.55
CHEMBL91372 — IC50 = 330.0 nM 6.48
CHEMBL328555 — IC50 = 340.0 nM 6.47
CHEMBL313650 — IC50 = 380.0 nM 6.42
CHEMBL90827 — IC50 = 400.0 nM 6.40
CHEMBL316308 — IC50 = 540.0 nM 6.27
CHEMBL86427 — IC50 = 540.0 nM 6.27
CHEMBL89687 — IC50 = 600.0 nM 6.22
CHEMBL89612 — IC50 = 610.0 nM 6.21
CHEMBL89386 — IC50 = 680.0 nM 6.17
CHEMBL316138 — IC50 = 710.0 nM 6.15
CHEMBL313951 — IC50 = 830.0 nM 6.08
CHEMBL329455 — IC50 = 870.0 nM 6.06
CHEMBL89609 — IC50 = 890.0 nM 6.05
CHEMBL88489 — IC50 = 950.0 nM 6.02
CHEMBL315903 — IC50 = 1020.0 nM 5.99
CHEMBL91437 — IC50 = 1100.0 nM 5.96
CHEMBL315270 — IC50 = 1220.0 nM 5.91
CHEMBL90619 — IC50 = 1300.0 nM 5.89
CHEMBL329320 — IC50 = 1360.0 nM 5.87
CHEMBL420981 — IC50 = 1600.0 nM 5.80
CHEMBL314521 — IC50 = 1700.0 nM 5.77
CHEMBL88599 — IC50 = 1700.0 nM 5.77
CHEMBL432379 — IC50 = 1700.0 nM 5.77
CHEMBL315556 — IC50 = 1870.0 nM 5.73
CHEMBL89523 — IC50 = 1920.0 nM 5.72
CHEMBL89269 — IC50 = 2100.0 nM 5.68
CHEMBL316339 — IC50 = 2100.0 nM 5.68
CHEMBL315098 — IC50 = 2390.0 nM 5.62
CHEMBL328363 — IC50 = 2500.0 nM 5.60
CHEMBL88864 — IC50 = 2600.0 nM 5.58
CHEMBL88865 — IC50 = 4400.0 nM 5.36
CHEMBL89671 — IC50 = 5000.0 nM 5.30
CHEMBL314448 — IC50 = 5400.0 nM 5.27
CHEMBL88727 — IC50 = 8200.0 nM 5.09
CHEMBL2370141 — IC50 = 22900.0 nM 4.64
CHEMBL32838 FUMAGILLIN IC50 > 100000.0 nM -