Assay Detail
Binding
CHEMBL872696
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Inhibition of Matrix metalloprotease-1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.91 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278060 | — | — | 1 | 6.95 |
| CHEMBL18614 | — | — | 1 | 6.94 |
| CHEMBL278872 | — | — | 1 | 6.71 |
| CHEMBL19371 | — | — | 1 | 5.91 |
| CHEMBL19279 | — | — | 1 | 5.81 |
| CHEMBL19005 | — | — | 1 | 5.79 |
| CHEMBL18667 | — | — | 1 | 5.78 |
| CHEMBL19278 | — | — | 1 | 5.72 |
| CHEMBL18649 | — | — | 1 | 5.63 |
| CHEMBL273764 | — | — | 1 | 5.60 |
| CHEMBL18943 | — | — | 1 | 5.49 |
| CHEMBL418737 | — | — | 1 | 5.42 |
| CHEMBL18895 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278060 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL18614 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL278872 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL19371 | — | IC50 | = | 1228.0 | nM | 5.91 |
| CHEMBL19279 | — | IC50 | = | 1534.0 | nM | 5.81 |
| CHEMBL19005 | — | IC50 | = | 1616.0 | nM | 5.79 |
| CHEMBL18667 | — | IC50 | = | 1658.0 | nM | 5.78 |
| CHEMBL19278 | — | IC50 | = | 1923.0 | nM | 5.72 |
| CHEMBL18649 | — | IC50 | = | 2364.0 | nM | 5.63 |
| CHEMBL273764 | — | IC50 | = | 2488.0 | nM | 5.60 |
| CHEMBL18943 | — | IC50 | = | 3203.0 | nM | 5.49 |
| CHEMBL418737 | — | IC50 | = | 3815.0 | nM | 5.42 |
| CHEMBL18895 | — | IC50 | = | 7803.0 | nM | 5.11 |