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Assay Detail

CHEMBL872712

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of thrombin
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Biaryl substituted alkylboronate esters as thrombin inhibitors
Quan M, Wityak J, Dominguez C, Duncia J, Kettner C, Ellis C, Liauw A, Park J, Santella J, Knabb R, Thoolen M, Weber P, Wexler R
Bioorg Med Chem Lett (1997) 7 : 1595 -1600
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 8.24 10.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290376 1 10.40
CHEMBL40854 1 9.68
CHEMBL290212 1 9.44
CHEMBL289318 1 9.38
CHEMBL41152 1 9.34
CHEMBL418071 1 9.04
CHEMBL276880 1 9.03
CHEMBL287964 1 8.96
CHEMBL290836 1 8.92
CHEMBL296663 1 8.89
CHEMBL264370 1 8.77
CHEMBL43140 1 8.46
CHEMBL297535 1 8.33
CHEMBL263204 1 8.31
CHEMBL289147 1 8.26
CHEMBL434971 1 8.16
CHEMBL290720 1 8.08
CHEMBL290378 1 8.00
CHEMBL40407 1 7.72
CHEMBL42852 1 7.58
CHEMBL297536 1 7.52
CHEMBL276881 1 7.38
CHEMBL290363 1 6.96
CHEMBL40364 1 6.86
CHEMBL289709 1 6.39
CHEMBL418427 1 6.29
CHEMBL288539 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290376 Ki = 0.04 nM 10.40
CHEMBL40854 Ki = 0.21 nM 9.68
CHEMBL290212 Ki = 0.36 nM 9.44
CHEMBL289318 Ki = 0.42 nM 9.38
CHEMBL41152 Ki = 0.46 nM 9.34
CHEMBL418071 Ki = 0.92 nM 9.04
CHEMBL276880 Ki = 0.94 nM 9.03
CHEMBL287964 Ki = 1.1 nM 8.96
CHEMBL290836 Ki = 1.2 nM 8.92
CHEMBL296663 Ki = 1.3 nM 8.89
CHEMBL264370 Ki = 1.7 nM 8.77
CHEMBL43140 Ki = 3.5 nM 8.46
CHEMBL297535 Ki = 4.7 nM 8.33
CHEMBL263204 Ki = 4.9 nM 8.31
CHEMBL289147 Ki = 5.5 nM 8.26
CHEMBL434971 Ki = 6.9 nM 8.16
CHEMBL290720 Ki = 8.3 nM 8.08
CHEMBL290378 Ki = 10.0 nM 8.00
CHEMBL40407 Ki = 19.0 nM 7.72
CHEMBL42852 Ki = 26.0 nM 7.58
CHEMBL297536 Ki = 30.0 nM 7.52
CHEMBL276881 Ki = 42.0 nM 7.38
CHEMBL290363 Ki = 110.0 nM 6.96
CHEMBL40364 Ki = 137.0 nM 6.86
CHEMBL289709 Ki = 410.0 nM 6.39
CHEMBL418427 Ki = 512.0 nM 6.29
CHEMBL288539 Ki = 580.0 nM 6.24