Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL872722

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against thrombin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Diarylsulfonamides as selective, non-peptidic thrombin inhibitors.
Weber IR, Neidlein R, von der Saal W, Grams F, Leinert H, Strein K, Engh RA, Kucznierz R.
Bioorg Med Chem Lett (1998) 8 : 1613 -1618
PubMed 9873400 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 5.84 7.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL24097 1 7.64
CHEMBL289790 1 6.75
CHEMBL23813 1 6.52
CHEMBL40704 1 6.20
CHEMBL290226 1 5.70
CHEMBL417348 1 5.19
CHEMBL40775 1 5.19
CHEMBL44521 1 5.16
CHEMBL43754 1 5.05
CHEMBL40373 1 5.00
CHEMBL417167 1 -
CHEMBL42069 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL24097 Ki = 23.0 nM 7.64
CHEMBL289790 Ki = 180.0 nM 6.75
CHEMBL23813 Ki = 300.0 nM 6.52
CHEMBL40704 Ki = 630.0 nM 6.20
CHEMBL290226 Ki = 2000.0 nM 5.70
CHEMBL417348 Ki = 6500.0 nM 5.19
CHEMBL40775 Ki = 6400.0 nM 5.19
CHEMBL44521 Ki = 7000.0 nM 5.16
CHEMBL43754 Ki = 9000.0 nM 5.05
CHEMBL40373 Ki = 9900.0 nM 5.00
CHEMBL417167 Ki = 170000.0 nM -
CHEMBL42069 Ki = 240000.0 nM -